1. Always accelerate gently.

2. Watch traffic ahead of you so you can anticipate slow-downs and avoid stops.
3. Coast up to traffic jams by lifting your foot off the gas pedal instead of approaching at full speed and slamming on the brakes. It takes 20% more gas to accelerate to normal speed from a full stop than it does from four or five miles per hour.
4. Don't drive too fast or too slow. It takes 20% to 30% more gas to drive at 70 mph than 50 mph.
5. Maintain a steady speed on the highway. Avoid getting stuck behind slow cars where you have to slow down to their pace and then speed up to pass.
Source: about.com